Oxford Recovery Center’s Approach
Oxford Recovery Center offers therapies that complement traditional cancer treatment to promote oxidation of cancer cells, slow or stop the progression of angiogenesis in regard to cancer stem cells while increasing angiogenesis and stem cells of normal, healthy cells. Our therapies help mitigate side effects of radiation and chemotherapy.
- The effect of oxygenation on the biological behaviour of tumours
- A combination of radiotherapy, nitric oxide and a hyperoxygenation sensitizing protocol for brain malignant tumor treatment
- Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK: A significant percentage of apoptosis were shown only in hematopoietic Jurkat and NCI-H929 cells after being treated with 6 hours of hbot at 2.5 to 3.5 ATA.
- Combination hyperbaric oxygen and temozolomide therapy in c6 rat glioma model:Hyperbaric oxygen (HBO) may enhance the efficacy of certain therapies that are limited because of the hypoxic tumor microenvironment. The combination of hyperbaric oxygen with temozolomide produced an important reduction in glioma growth and
effective approach to the treatment of glioblastoma.
- Effects of the combination of hyperbaric oxygen and 5-fluorouracil on proliferation and metastasis of human nasopharyngeal carcinoma CNE-2Z cells: Investigatingthe effects of hyperbaric oxygen (HBO2) and/or 5-fluorouracil (5-FU) on theproliferation and metastasis of human nasopharyngeal carcinoma (NPC) cell line CNE2Z and the underlyingmechanisms involved. Simple HBO2 treatment after 48 and 72 hours could inhibit the proliferation of nasopharyngeal carcinoma CNE2Z cells.
- Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation: This study aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene expression. Tumor growth was significantly inhibited by HBO, and the MAPK pathway was found to be significantly reduced.
- Hyperbaric Oxygen: A potential new therapy for leukemia?: HBO2 was used successfully over 30 years ago as a radiosensitizer in clinical trials of head and neck cancer and cervical cancer performed by the British Medical Research Council.HBO2 induces apoptosis in the Jurkat T-cell leukemia and the NCI-H929 myeloma cell lines, which confirms the earlier report demonstrating that HBO2 induces spontaneous, radiation-induced, and chemotherapy-induced apoptosis in Jurkat and HL-60 promyelocytic leukemia cells.
- Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma: This study investigated the efficacy of hyperbaric oxygen alone and in combination with an anti-cancer drug as an adjuvant to chemotherapy. After 5 weeks, increase in both tumor volume and number of lung metastases was significantly suppressed in the hyperbaric oxygen group.
- Hyperbaric Oxygen Inhibits Benign and Malignant Human Mammary Epithelial Cell Proliferation: We used an in vitro model to examine the effects of HBO on mammary cell proliferation. HBO inhibits benign and malignant mammary epithelial cell proliferation, but does not enhance cell death.
- Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressions: Increased oxygenation of the hypoxic tumor may have an inhibitory effect on STAT3 activation and hence tumor-growth inhibition. HBO exposure, in combination with weekly administration of cisplatin, significantly reduced the tumor volume.
- Hyperbaric oxygen reduces COX-2 expression in a dimethylhydrazine-induced rat model of colorectal carcinogenesis.: Hyperbaric oxygen (HBO2) therapy is indicated as adjuvant treatment for infectious diseases as well as hypoxic and inflammatory lesions. COX-2 expression was “induced” by DMH and reverted to a “wild”-type level of expression upon exposure to HBO2.
- Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors: This study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors. Tumor growth was significantly reduced (~57–66 %) after hyperoxic treatment compared to control and even more than 5-FU (~36 %).
- Hyperoxia retards growth and induces apoptosis, changes in vascular density and gene expression in transplanted gliomas in nude rats: This study describes the biological effects of hyperoxic treatment on BT4C rat glioma xenografts. In both the 1 and 2 bar hyperoxic treatment groups (total 4.5 h) a ~60% reduction in growth compared to control was observed.
- Hypoxic radiosensitization: Adored and Ignored: solid tumors may contain oxygen-deficient hypoxic areas and that cells in such areas may cause tumors to become radioresistant. Controlled clinical trials during the last 40 years have indicated that this source of radiation resistance can be eliminated or modified by hyperbaric oxygen.
- Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway: Several strategies to improve tumor oxygenation were developed such as breathing high oxygen content gas under hyperbaric conditions. A meta-analysis of all randomized trials in which some form of hypoxic modification was performed, showed an improved local control and survival, especially in cervix and head-and-neck cancer.
- Lung metastatic load limitation with hyperbaric oxygen:We evaluated the growth of murine breast cancer cells in the lung after hyperbaric oxygen treatment in an experimental metastasis assay. A significant reduction in the number of the large colonies was observed at 1 and 16 to 21-day periods of measurements after hyperbaric treatment.
- Management of Brain Abcesses in Children Treated for Acute Lymphoblastic Leukemia: In this study, 4 patients received multimodal broad-spectrum antibiotic therapy and liposomal amphotericin-B in combination with hyperbaric oxygen. All four patients survived, with two patients showing complete resolution of neurological and MRI abnormalities and with two patients still having residual lesions.
- Role of elevated pressure in TRAIL-induced apoptosis in human lung carcinoma cells: In the present study, we describe a custom-designed culture system that delivers two atmospheres of elevated pressure (EP) by using compressed air, and which enhances the sensitivity of cancer cells to TRAIL-mediated apoptosis. The findings suggest that EP is a mechanical and physiological stimulus that might have utility as a sensitizing tool for cancer therapy.
- The Oxygen effect: An old new target?: Tumor hypoxia is a limiting treatment factor. Multiple ways to interact with free radicals have been developed. Studies on the expression of endogenous markers of hypoxia could be useful tools to predict tumour response to the treatment.
- [Utility of hyperbaric oxygenation in radiotherapy for malignant brain tumors–a literature review]: In the treatment of
malignant gliomas, HBO therapy is used for the radiosensitization of cells in combination with radiotherapy. Further, HBO therapy is applied for the treatment and prevention of radiation-induced brain necrosis that is the most serious complication observed after radiosurgery.
- Carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: Long-term tumor control and complications: Patients with locally advanced laryngeal carcinoma were treated with hypofractionated radiation and hyperbaric oxygen at 4 atmosphers of pressure (HBO-4). The 10-year survival of the overall population was 27%. The 10-year voice preservation rate for the 39 complete responders was 55%.
- Long-term experience of hyperbaric oxygen therapy for refractory radio- or chemotherapy-induced haemorrhagic cystitis: We retrospectively reviewed 15 patients referred for HBOT for haemorrhagic cystitis (HC). HBOT was performed for 130 min per day at a pressure of 2.4 atmospheres. Our experience indicate that HBOT is a safe and effective therapeutic option for treatment-resistant radiogenic and chemotherapy-induced haemorrhagic cystitis.
- Hyperbaric Oxygen Therapy and Cancer – A Review: Hyperbaric oxygen (HBO) treatment has for centuries been used to improve or cure disorders involving hypoxia and ischemia, by enhancing the amount of dissolved oxygen in the plasma and thereby increasing O delivery to the tissue. There is evidence that implies that HBO might have tumor-inhibitory
effects in certain cancer subtypes.
- Sustained Radiosensitization of Hypoxic Glioma Cells after Oxygen Pretreatment in an Animal Model of Glioblastoma and In Vitro Models of Tumor Hypoxia: We evaluated the concept that pre-treating tumor tissue by transiently elevating
tissue oxygenation prior to radiation exposure could increase the efficacy of radiotherapy.
- Ketogenic Diet in Combination with Calorie Restriction and Hyperbaric Treatment Offer New Hope in Quest for Non-Toxic Cancer Treatment:A mounting body of evidence suggests cancer is responsive to therapeutic ketosis—a natural physiologic state induced during prolonged states of decreased glucose. Cancer patients also need to combine a ketogenic diet with calorie restriction to achieve glucose depletion that will effectively starve the cancer cells. Recent research also shows that adding hyperbaric oxygen treatment will dramatically reduce cancer growth and shrink tumors.
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